The position will consist of conducting longitudinal twin studies using data from 3 aging studies in the Swedish Twin Registry (the Swedish Adoption/Twin Study of Aging, OCTO-Twin, and GENDER) to test whether physiological dysregulation mediates effects of social isolation on Alzheimer’s disease risk. Additionally, there will be opportunity to conduct cross-sectional and longitudinal studies to identify potential sex differences in genetically and environmentally influenced risk factors (e.g., education status, midlife health behaviors) correlated with dementia and Alzheimer’s disease risk using data from 10 studies in the Interplay of Genes and Environments Across Multiple Studies (IGEMS) Consortium. Proficiency in R and/or Mplus required.