Skirting Mendel: Non-Classical Mechanisms of Phenotypic Variation, Inheritance and Disease, hosted by Keystone Symposia will be held March 15 –19, 2020 at Whistler Conference Center in British Columbia, Canada. This is an exciting program that will appeal to geneticists, epigenomicists, chromatin biologists, developmental biologists, mathematicians, physiologists and clinical scientists. The symposium will be hosted together with the Higher-Order Chromatin Architecture in Time and Space.  You can find all of the details and registration information at keystonesymposia.org/20X4. The registration date is just weeks away (Feb1) and there are still short talk slots available.

**The speaker list for the variation half of the meeting is below!

Welcome and Keynote Address (X4)

Stanislas Leibler, Rockefeller – Bet Hedging, Variation and Generational Effects on Evolution

Non-Mendelian Variation in Humans (X4)

Emma Farley, UCSD  –  High-Throughput Genotype to Phenotype Assays to Pinpoint Enhancer Mutations Underlying Disease

Jordana T. Bell, King’s College – Heritable and Non-Heritable Variation: Lessons from Twins

Robert A. Waterland, Baylor  – Environmental Effects on Stochastic Establishment of DNA Methylation in Humans

Short Talks Chosen from Abstracts

The Repeat Genome, Heritability and the Stabilization of Phenotypes (X4)

Maria-Elena Torres-Padilla, Helmholtz – Epigenetic Mechanisms of Cellular Plasticity and Reprogramming to Totipotency

Anne C. Ferguson-Smith, Cambridge – Epigenetic Variation at Repeats within and across Generations

Robert A. Martienssen, CSHL – Regulation of Transposons in Eukaryotes: Functions and Implications

Short Talks Chosen from Abstracts

Poster Session 1

 Modelling Bi-Stability, Buffering, Bursting (X4)

Martin Howard, John Innes Centre, – Dissecting the Mechanistic Basis of Polycomb Nucleation and Spreading: Fusing Mathematical Modelling with Experiments

Speaker to be Announced

Vincent Colot, École Normale Supérieure, – Inheritance Patterns and Phenotypic Consequences of DNA Methylation Variation in Arabidopsis

Lucia Clemens-Daxinger, Leiden  – (Epi)genetics of Parental Effects

Short Talks Chosen from Abstracts

 Mechanisms of Tuning Variation I – Quantitative in vivo Systems (X4)

Shelley L. Berger, UPenn – From Ants to Cancer Evolution: Epigenetic Systems Control

Oded Rechavi, Tel Aviv University – Transgenerational Memory in C.elegans

Eric A. Miska, Cambridge – Cichlid Evolutionary Radiation

Short Talks Chosen from Abstracts

Poster Session 2

 Inter- / Trans-Generational Mechanisms (X4)

Oliver J. Rando, UMass – Paternal Mechanisms of Intergenerational Control in Mice

Ben Lehner, CRG – Understanding Genotype-Phenotype Maps Using Deep Mutagenesis

Qi Chen, UC Riverside – Sperm RNA Code: How Many Secrets in Programming Offspring Phenotypes?

Coleen T. Murphy, Princeton – C. elegans uses Bacterial Small RNAs and RNA Interference to “Read” and Remember the Microbiome

Short Talks Chosen from Abstracts

Histone-Based Mechanisms of Rewiring and Feedback (X4)

Robert Schneider, Helmholtz – Capturing Transcriptional Memories, One-Cell at a Time

Victor G. Corces, Emory – Mechanisms of Transgenerational Inheritance of Obesity Epiphenotypes

Mofang Liu, SIBS –Piwi, a New Disease Factor in Human Male Infertility?

Short Talks Chosen from Abstracts

Mechanisms of Tuning Variation II: Buffering and Canalizing Genetic Programs (X4)

J. Andrew Pospisilik, VAI – Epigenetic Underpinnings of Metabolic Disease Heterogeneity

Daniel F. Jarosz, Stanford – Protein Folding, Environmental Stress, and the Diversification of Phenotype

Ralf Sommer, – Predatory Feeding Plasticity in Nematodes: Genetics, Epigenetics and Trans-Generational Effects

Matthew C. Lorincz, UBC – Chromatin-Guided De Novo Methylation in the Mammalian Gerrmline and Beyond

Short Talk Chosen from Abstracts

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Parallel Meeting (also open to attendees) – Higher order Chromatin

Welcome and Keynote Address (X3)

Xiaowei Zhuang, Harvard                                 – Imaging the 3D Organization of the Genome

Genome Reconfiguration in the Cell Cycle (X3)

Job Dekker, University of Massachusetts Medical School, USA Genome Folding and Re-Folding during the Cell Cycle

Gerd A. Blobel, Children’s Hospital of Philadelphia, USA Principles of Chromatin Organization through the Lens of the Cell Cycle
Amos Tanay, Weizmann Institute, Israel
Single Cell Hi-C Deconvolutes Proliferation and Differentiation in Embryonic Mesoderm, Ectoderm and Blood Chromosome Conformations
Short Talks Chosen from Abstracts

Workshop 1: Leading Computational Methods to Identify Biologically Relevant Patterns in Hi-C Data (X3)

Short Talks Chosen from Abstracts

Causes and Consequences of Genome Folding on Genome Function (X3)

Daniele Canzio, University of California, San Francisco, USA
The Role of Chromosome Architecture in Generating a Code for Neural Self-Recognition

Jennifer E. Phillips-Cremins, University of Pennsylvania, USA Connecting 3D Genome Structure to Repeat Instability in Neurological Disorders

Bas van Steensel, Netherlands Cancer Institute, Netherlands Dynamics of Lamina-Associated Domains.

Short Talks Chosen from Abstracts

Genome Misfolding in Human Disease (X3)

Nancy E. Kleckner, Harvard University, USA Chromosomes as Mechanical Objects

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany Genome Architecture Mapping Detects Extensive Allele-Specific Chromatin Contacts in Hybrid mESCs

Benoit G. Bruneau, Gladstone Institutes, USA – Chromatin Organization in Heart Development

Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA Cohesin Loading and Transcriptional Regulation

Short Talks Chosen from Abstracts

Visualizing Genome Folding in Single Cells (X3)

Ting (C.-ting) Wu, Harvard Medical School, USA Such a Lot of Genome to See…

Clodagh C. O’Shea, The Salk Institute for Biological Studies, USA ChromEMT: Visualizing 3D Chromatin Structure and Compaction of the Human Genome in Interphase and Mitotic Cells

Long Cai, California Institute of Technology, USA – Simultaneous Visualization of Gene Expression and Genome Structure in Single Cells

Short Talks Chosen from Abstracts

Mechanisms Governing Long-Range Looping (X3)

Bing Ren, Ludwig Institute for Cancer Research, USA Long-Range Regulation of Enhancer Promoter Interaction

Stavros Lomvardas, Columbia University, USA Role for Genome Folding in Olfaction

François Spitz, Institut Pasteur, France
Functions and Regulation of 3D Genome Architecture

Suzana Hadjur, University College London, UK
Chromatin Topology Regulation and Stem Cell State Plasticity

Short Talks Chosen from Abstracts

Spatiotemporal Genome Folding Dynamics (X3)

Joanna Wysocka, Stanford University, USA – Long-range gene regulation by enhancers

Bradley R. Cairns, HHMI/University of Utah, USA – Mechanisms for Establishing Developmental Gene Poising/Silencing and Chromosome Architecture in Early Zebrafish Embryos

Karen L. Reddy, Johns Hopkins University, USA –Dynamic Spatiotemporal Organization of LADs and Lamins after Mitosis

Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA –Folding and Unfolding the X-Chromosome Origami

Poster Session 3

Phase Separation in the 3D Nucleus (X3)

Clifford P. Brangwynne, Princeton University, USA – Optical Control over Nuclear Bodies

Leonid Mirny, Massachusetts Institute of Technology, USA – Biophysical Mechanisms of Chromosome Organization

Gary Karpen, Berkeley, – Do Liquid-Like Properties Regulate Genome Organization and Function?